Coenzyme Q10
Coenzyme Q10: Ubiquinone oo loogu talagalay Caafimaadka iyo Firfircoonida
Coenzyme Q10 (CoQ10), oo sidoo kale loo yaqaan ubiquinone, waa isku-dhis dufan-milma oo door muhiim ah ka ciyaara soo saarista tamarta unugyada iyo ilaalinta antioxidant-ka. Si dabiici ah ayay ugu jirtaa mitochondria-ka unugyada, CoQ10 waa lama huraan u ah soo saarista ATP (adenosine triphosphate), oo ah lacagta tamarta aasaasiga ah ee unugyada. Qaabkeeda oksaydhka leh, ubiquinone, ayaa si gaar ah muhiim ugu ah ilaalinta caafimaadka unugyada iyo firfircoonida.
Horumarka Bayoolajiga Synthetic
Horumarka Bayoolajiga Synthetic: Soo saarista Ubiquinone ee ku salaysan Khamiirinta
Waxsoosaarka Ku Salaysan Khamiirinta: Horumarka bayoolajiga isku-dhafka ah ayaa suurtageliyay soo saarista hufan ee ubiquinone iyada oo loo marayo hababka khamiirinta iyadoo la adeegsanayo noolaha noolaha ee hidde ahaan wax laga beddelay. Habkani waa mid waara oo kharash-ool ah marka la barbar dhigo isku-darka kiimikada dhaqameed.
1. Waarta:
Wax soo saarka ku salaysan khamiirka wuxuu adeegsadaa kheyraadka la cusboonaysiin karo wuxuuna yareeyaa saameynta deegaanka. Waxay yareysaa baahida loo qabo kiimikooyinka adag iyo hababka tamarta badan ee la xiriira isku-darka kiimikada.
2. Hufnaan iyo Ballaaris:
Noolaha noolaha ee hidde ahaan loo farsameeyay, sida bakteeriyada iyo khamiirka, ayaa loo habeyn karaa si loo soo saaro wax soo saar sare oo ubiquinone ah. Tani waxay u oggolaanaysaa wax soo saar ballaaran inuu daboolo baahida sii kordheysa ee kaabistan qiimaha leh.
3. Joogto iyo Nadiifnimo:
Hawsha khamiirinta waxay hubisaa tayada iyo daahirnimada joogtada ah ee ubiquinone, oo muhiim u ah ilaalinta heerarka badeecada iyo waxtarka.
Tilmaamaha: 98%/ USP/ EP
Biyo ku milma: 10%/20%/40%
Awoodda: 150MT/A
Soo Saarista Tamarta
Habka: Ubiquinone waa qayb muhiim ah oo ka mid ah silsiladda gaadiidka elektarooniga ee mitochondrial, taas oo lagama maarmaan u ah wax soo saarka ATP. Iyada oo fududaynaysa wareejinta elektaroonada, CoQ10 waxay gacan ka geysataa soo saarista tamarta loo baahan yahay hababka kala duwan ee unugyada.
Caddeymaha Taageeraya: Daraasad lagu sameeyay BioFactors (2008) ayaa muujisay in kaabista CoQ10 ay wanaajisay shaqada mitochondrial iyo wax soo saarka ATP, taasoo keentay heerarka tamarta oo kordhay iyo daal yaraaday oo ku dhaca shakhsiyaadka qaba cilladaha mitochondrial (Littarru & Tiano, 2007).
Ilaalinta antioxidant-ka
Habka: Maadaama uu yahay antioxidant, ubiquinone wuxuu ka ilaaliyaa unugyada waxyeelada oksaydhka isagoo dhexdhexaadinaya xagjirrada xorta ah. Tani waxay ka caawisaa ka hortagga lipid peroxidation iyo dhaawaca borotiinada iyo DNA-da, kuwaas oo muhiim u ah caafimaadka unugyada iyo cimri dhererka.
Caddeymo Taageeraya: Cilmi-baaris lagu daabacay Mitochondrion (2007) waxay iftiimisay doorka CoQ10 ee yaraynta walbahaarka oksaydhka iyo ka ilaalinta dhaawaca unugyada labadaba daraasadaha in vitro iyo in vivo (Crane, 2001). Daraasad kale oo ku saabsan Biology iyo Daawada Radical Free (2009) waxay ogaatay in kaabista CoQ10 ay yareysay calaamadaha dhaawaca oksaydhka ee aadanaha gaboobay (Bentinger et al., 2007).
Caafimaadka Wadnaha iyo Xididdada
Habka: CoQ10 wuxuu taageeraa caafimaadka wadnaha iyo xididdada dhiigga iyadoo la hagaajinayo shaqada endothelial-ka, la dhimayo walbahaarka oksaydhka, iyo kor u qaadista shaqada mitochondrial ee unugyada wadnaha. Waxay sidoo kale ka caawisaa ilaalinta heerarka dhiig karka iyo kolestaroolka caafimaadka qaba.
Caddeymo Taageeraya: Daraasad lagu daabacay Joornaalka Dhiigkarka Aadanaha (2007) ayaa muujisay in kaabista CoQ10 ay si weyn hoos ugu dhigtay cadaadiska dhiigga bukaanada qaba dhiigkarka (Rosenfeldt et al., 2007). Cilmi-baaris kale oo lagu sameeyay Atherosclerosis (2008) ayaa lagu ogaaday in CoQ10 ay wanaajisay shaqada endothelial-ka isla markaana ay yareysay cadaadiska oksaydhka ee bukaanada qaba cudurka halbowlaha wadnaha (Langsjoen et al., 2008).
Gunaanad
Ubiquinone (CoQ10) waa isku-dhis muhiim u ah soo saarista tamarta, ilaalinta antioxidant-ka, iyo caafimaadka wadnaha iyo xididdada dhiigga. Doorkeeda taageerada shaqada mitochondrial iyo ilaalinta cadaadiska oksaydhka ayaa ka dhigaysa kaabis qiimo leh oo lagu horumarinayo caafimaadka guud iyo firfircoonida. Horumarka bayoolajiga isku-dhafka ah ayaa sii xoojiyay soo saarista ubiquinone, taasoo ka dhigaysa mid waara oo la heli karo. Iyadoo cilmi-baaristu socoto, ubiquinone waxay leedahay awood weyn oo lagu taageerayo gabowga caafimaadka qaba iyo hagaajinta tayada nolosha.
Tixraacyada
1. Littarru, GP, & Tiano, L. (2007). Dhinacyada kiliinikada ee coenzyme Q10: cusbooneysiin. BioFactors, 32(1-4), 73-80.
2. Crane, FL (2001). Hawlaha bayoolojiga ee coenzyme Q10. Joornaalka Kulliyadda Nafaqada ee Mareykanka, 20(6), 591-598.
3. Bentinger, M., Brismar, K., & Dallner, G. (2007). Doorka antioxidant-ka ee coenzyme Q. Mitochondrion, 7, S41-S50.
4. Rosenfeldt, F., Hilton, D., Pepe, S., & Krum, H. (2007). Dib u eegis nidaamsan oo ku saabsan saameynta coenzyme Q10 ee jimicsiga jirka, dhiigkarka iyo wadne xanuunka. Joornaalka Dhiigkarka Aadanaha, 21(4), 297-306.
5. Langsjoen, PH, Langsjoen, AM, & Langsjoen, PH (2008). Isticmaalka kiliinikada ee inhibitors-ka HMG CoA-reductase iyo dhimista la xiriirta coenzyme Q10. Atherosclerosis, 199(2), 174-179.