Fisetin
Fisetin: Ka-hortagga oksaydheynta ee Caafimaadka iyo Muddada Dheer
Fisetin, oo ah flavonoid dabiici ah oo laga helo miro iyo khudaar kala duwan sida strawberries, tufaax, iyo basasha, ayaa dareen badan ka helaya faa'iidooyinkeeda caafimaad ee cajiibka ah. Iyadoo loo yaqaan antioxidant-ka awoodda badan, ka hortagga bararka, iyo sifooyinka senolytic, fisetin waxaa lagu darayaa awooddiisa ay ku taageeri karto cimriga dheer iyo yareynta cudurrada la xiriira da'da.
Qaybaha ugu Muhiimsan ee Fisetin
Fisetin laftiisu waa qaybta firfircoon ee flavonoid-ka oo mas'uul ka ah faa'iidooyinka caafimaad ee kala duwan. Waxaa loo yaqaan kiimiko ahaan 3,3', 4', 7-tetrahydroxyflavone. Qaab-dhismeedkeeda molecular-ka ayaa u oggolaanaya inuu la falgalo waddooyin kala duwan oo bayooloji ah, taasoo horseedaysa saameynteeda daaweynta ee kala duwan.
Codsiyada Kaabayaasha Cuntada
Fisetin waxaa badanaa loo isticmaalaa kaabista cuntada ee loogu talagalay taageeridda caafimaadka maskaxda, yaraynta caabuqa, iyo kor u qaadida cimriga. Qiyaasta lagu taliyay way kala duwan tahay, laakiin badanaa waxay u dhaxaysaa 100 ilaa 500 mg maalintii, iyadoo ku xiran qaacidada gaarka ah iyo isticmaalka loogu talagalay.
Tilmaamaha: 50% -98% (HPLC)
Awoodda: 50MT/A
Saamaynta antioxidant-ka iyo ka hortagga bararka
Habka: Fisetin wuxuu sameeyaa firfircooni xooggan oo ka hortagga oksaydhka isagoo baabi'inaya xagjirrada xorta ah isla markaana kor u qaadaya firfircoonida ensaymada oksaydhka ee endogenous antioxidant. Waxa kale oo uu yareeyaa bararka isagoo hor istaagaya soo saarista cytokines-ka ka hortagga bararka iyo hoos u dhigista waddooyinka bararka sida NF-κB.
Caddeynta Taageeraysa: Daraasad lagu sameeyay Molecules (2019) waxay iftiimisay awoodda fisetin ee lagu yareeyo walbahaarka oksaydhka iyo bararka noocyada kala duwan ee unugyada iyo xayawaanka, taasoo soo jeedinaysa awooddeeda ay ku ilaalin karto cudurrada daba-dheeraada (Khan et al., 2019).
Ilaalinta neerfaha
Habka: Fisetin wuxuu taageeraa caafimaadka maskaxda isagoo kor u qaadaya neerfaha, yareynaya bararka neerfaha, iyo ka hortagga dhaawaca neerfaha. Waxay xoojisaa xusuusta iyo shaqada garashada iyadoo wax ka beddesha waddooyinka calaamadaha ee ku lug leh dabacsanaanta synaptic.
Caddeynta Taageeraysa: Cilmi-baaris ku saabsan Xuduudaha ku jira Gabowga neerfaha (2016) waxay muujisay in fisetin uu wanaajiyay shaqada garashada iyo inuu yareeyay bararka neerfaha ee noocyada xayawaanka ee cudurka Alzheimers, taasoo muujinaysa awooddiisa ah wakiil ka hortagga neerfaha (Currais et al., 2016).
Dhaqdhaqaaqa Dareenka Ba'an
Habka: Fisetin wuxuu kiciyaa apoptosis unugyada gabowga, kuwaas oo ah unugyo joojiyay kala qaybsanaanta oo gacan ka geysta gabowga iyo cudurada la xiriira da'da. Iyadoo la nadiifinayo unugyadan aan shaqaynayn, fisetin wuxuu gacan ka geystaa hagaajinta shaqada unugyada iyo yareynta bararka.
Caddeymo Taageeraya: Daraasad lagu daabacay EBioMedicine (2018) ayaa muujisay in fisetin uu si xushmad leh u baabi'iyay unugyada gabowga iyo hagaajinta cimriga caafimaadka iyo cimriga ee jiirarka, taasoo soo jeedinaysa doorkeeda kor u qaadista gabowga caafimaadka qaba (Yousefzadeh et al., 2018).
Gunaanad
Fisetin waa flavonoid awood badan leh oo leh faa'iidooyin caafimaad oo ballaaran, oo ay ku jiraan antioxidant, anti-bararka, neuroprotective, iyo senolytic. Awooddeeda ay ku hagaajin karto marinno badan oo bayooloji ah ayaa ka dhigaysa musharrax rajo leh oo kor u qaadaya caafimaadka iyo cimri dhererka. Cilmi-baarista socota waxay sii waddaa inay soo bandhigto adeegsigeeda suurtagalka ah ee ka hortagga iyo daaweynta xaaladaha kala duwan ee la xiriira da'da.
Tixraacyada
1. Khan, N., Afaq, F., & Mukhtar, H. (2019). Fisetin: Antioxidant cunto oo loogu talagalay kor u qaadista caafimaadka. Molecules, 24(6), 1004.
2. Currais, A., Prior, M., Dargusch, R., Armando, A., Ehren, J., Schubert, D., & Maher, P. (2016). Isbeddelka p25 iyo waddooyinka bararka ee fisetin wuxuu ilaaliyaa shaqada garashada ee jiirarka transgenic ee cudurka Alzheimers. Xuduudaha Gabowga Neuroscience, 8, 96.
3. Yousefzadeh, MJ, Zhu, Y., McGowan, SJ, Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., ... & Robbins, PD (2018). Fisetin waa daawo neefsasho oo dheereysa caafimaadka iyo cimriga. EBioMedicine, 36, 18-28.