Is-afgaradka Sayniska ee Caalamiga ah ayaa Xaqiijiyay Faa'iidooyinka Caafimaadka ee Nidaamyada Badan ee Quercetin: FDA & Ansixinta Sharciyeynta Caalamiga ah ee Waddada u Marta Codsiyada Caafimaadka

Meelaha caddaynta lagu rakibayo quercetin— flavonoid xooggan oo laga helo dhirta — oo ah saldhig u ah la dagaallanka cudurrada la xiriira da'da iyada oo loo marayo habaynta bartilmaameedka ah ee walbahaarka oksaydhka, bararka, iyo cilladda dheef-shiid kiimikaadka. Oggolaanshaha sharciyeynta (FDA, Japan, Kuuriya) waxay xaqiijinayaan badbaadada sida Kaabis Cunto.

I. Ilaha Dabiiciga ah & Astaanta Bayoolojiga

• Ilaha Muhiimka ah (Celceliska qaadashada maalinlaha ah: 25–50 mg):
  Basasha (>100 mg/100g), tufaax, shaah cagaaran, jeeriga, canab cas, cilantro.
• Bayooloji firfircooni:
  5 kooxood oo hydroxyl ah ayaa awood u siinaya dhexdhexaadinta xagjirka xorta ah (H₂O₂, O₂⁻), iyagoo ka sarreeya antioxidants-ka caadiga ah.

II. Hababka Ficilka: Waddooyinka Molekulerka

① Nidaamka Difaaca Antioxidant

• Waxay kicisaa wadada Nrf2/ARE → ↑SOD/GPx muujinta
• Waxay joojisaa isu-imaatinka oxidase-ka NADPH (NOX) → ↓ Soo saarista ROS 68% (Gabowga Unugga, 2023)

② Aqoonta Ka-hortagga Caabuqa

• Waxay xakameysaa calaamadaynta NF-κB → ↓TNF-α/IL-6 (70% hoos u dhac ku yimaada moodooyinka cudurka psoriasis ee murqaha)
• Baloogyada fosfoorasaydhka STAT3 → Joojinta dhidibka IL-23/IL-17A

III. Adeegsiga Daaweynta ee Cudurrada oo dhan

IV. Xalalka iyo Badbaadada Helitaanka Bayoolojiga

• Caqabadda Nuugista: 5–10% saldhiga → 81% iyada oo loo marayo:
  • Hawo-ku-shubista Glycoside
  • Isku-dubaridka Faytamiin C/dufanka
• Qiyaasta: ≤1,000 mg/maalintii (Qiyaasaha sare waxay halis u yihiin saamaynta oksaydhka)
• Isdhexgalka Daroogada: Waxaa ka reeban antibiyootikada/ka-hortagga xinjirowga

V. Tilmaamaha Mustaqbalka: Bixinta Saxnaanta

• Nano-Encapsulation (PLGA/liposomes) waxay kor u qaadaa bartilmaameedka burooyinka
• Isku-dhafka FDA-ansixisay: Quercetin- isku-dhafka phosphatidylcholine (US5043323)