Nikotinamide Adenine Dinucleotide Hydrate
β-NADH, oo ah nooca firfircoon ee bayooloji ahaan ee fiitamiin B3 (niacin), waa coenzyme muhiim u ah hababka wax soo saarka tamarta unugyada jirka. Waxay door muhiim ah ka ciyaartaa silsiladda gaadiidka elektarooniga ee mitochondrial, iyadoo ka caawisa in nafaqooyinka loo beddelo tamar. β-NADH waxaa badanaa loo isticmaalaa kaabisyada kor u qaadista tamarta, shaqada garashada, iyo taageeridda caafimaadka guud ee unugyada.
Tilmaamaha: 99%
Waxay kordhisaa wax soo saarka tamarta unugyada: β-NADH waxay xoojisaa shaqada mitochondrial, iyadoo kordhinaysa wax soo saarka ATP (tamarta), taasoo horseedi karta tamar jireed iyo maskaxeed oo horumarsan【Birkmayer et al., 2009】.
Waxay hagaajisaa shaqada garashada: Daraasaduhu waxay soo jeedinayaan in β-NADH ay taageeri karto caafimaadka maskaxda iyadoo hagaajinaysa cadaynta maskaxda, diiradda saarista, iyo xusuusta, gaar ahaan dadka da'da ah【Birkmayer et al., 1999】.
Waxay taageertaa caafimaadka wadnaha iyo xididdada dhiigga: NADH waxay ku lug leedahay ilaalinta shaqada wadnaha ee caafimaadka qaba iyadoo kor u qaadaysa isticmaalka tamarta hufan ee unugyada muruqa wadnaha"Ziegler et al., 2000".
Saamaynta antioxidant-ka: NADH waxay ka caawisaa yareynta walbahaarka oksaydhka waxayna ka ilaalin kartaa unugyada waxyeelada ay keento xagjirrada xorta ah, taasoo gacan ka geysaneysa faa'iidooyinka ka hortagga gabowga【Braidy et al., 2019】.
Farsamooyinka
β-NADH wuxuu u dhaqmaa sidii coenzyme muhiim u ah falcelinta redox ee silsiladda gaadiidka elektarooniga ee mitochondrial. Waxay elektaroonada ugu deeqdaa isku-dhafka I, taasoo sahlaysa soo saarista ATP, oo ah side-ka tamarta ugu weyn ee unugyada. NADH waxay sidoo kale door ka ciyaartaa yaraynta walbahaarka oksaydhka iyadoo saameyn ku yeelanaysa nidaamyada antioxidant-ka, sida dib u soo noolaynta glutathione, kaas oo muhiim u ah ilaalinta unugyada waxyeelada【Birkmayer et al., 2009】【Braidy et al., 2019】.
Tixraacyada
Birkmayer, GD, et al. (1999). NADH waxay hagaajisaa shaqada garashada ee bukaanada Alzheimers. Joornaalka Gudbinta Dareemayaasha.
Birkmayer, JG (2009). NADH, Koenzyme-ka Tamarta: Xisaabinta Doorka ay ku leedahay Shaqada Unugyada iyo Adeegsiga Daaweynta. Springer.
Ziegler, M., et al. (2000). Doorka NADH ee Dheef-shiid kiimikaadka Tamarta iyo Caafimaadka Wadnaha. Cilmi-baarista iyo Dhaqanka Wadnaha.
Braidy, N., et al. (2019). Dheef-shiid kiimikaadka NAD+ ee neerfaha iyo cudurka mitochondrial. Neurochemistry International.